Improved estrogen metabolism with DIM produces more good estrogen metabolites, which compete with testosterone for protein binding, helping to maintain a slightly higher free testosterone level. This is relevant because active, or free, testosterone in women is closely linked to positive mood, interest in sex, and an active aerobic metabolism. Also, a sluggish estrogen metabolism can reduce the action of the small amount of testosterone present in women. Over the long term, maintaining a healthy metabolism of estrogen lowers the risk of breast cancer and uterine cancer.Ī reduced metabolism of estrogen may cause problems such as trouble sleeping excessive periods, or tender breasts. This metabolic state that favors muscle growth is called “anabolism.” Individuals with stronger muscles have a greater capacity to burn fat and maintain a youthful, lean body composition.Įstrogen’s healthy metabolism supports better functioning, improved mood, healthy fat metabolism, healthy heart and circulation, and better memory. “Free,” or non-protein-bound, testosterone and 2-hydroxy estrogen metabolites provide a hormonal signal for muscles to grow by adding more of the structural protein needed for size, strength, and movement. This occurs because good estrogen metabolites support the process of programmed cell death in which damaged cells are naturally eliminated from the body.ĭIM has also been shown to help control viral infections, support immune function and reduce certain forms of inflammation.ĭIM contributes to a better metabolism in the most natural way possible by working with your hormones and adjusting their action to avoid hormonal imbalance.īy supporting more efficient fat metabolism and helping testosterone to be liberated from its carrier proteins, these metabolites increase the development of stronger and more metabolically active muscles. The good estrogen metabolites are natural regulators of energy metabolism – they promote the active release of stored fat for better energy during exercise.Īnother unique attribute of the good estrogen metabolites is their ability to regulate cell growth, helping to get rid of damaged cells. Greater production of these bad estrogens is promoted by obesity and exposure to a number of man-made environmental chemicals. These include the 16-hydroxy and 4-hydroxy estrogens which are not antioxidants and can actually cause cancer. When DIM increases the 2-hydroxy estrogens, there is a simultaneous reduction of undesirable, or bad, estrogen metabolites. Many of the benefits that are attributed to estrogen, including its ability to protect the heart and brain with its antioxidant activity, are now known to come from these good metabolites. Good metabolites are known as 2-hydroxy estrogens. Estrogen requires a metabolic pathway similar to that needed by DIM and other natural indoles. To be modified into its final forms for passage out of the body, estrogen must be combined with oxygen as part of aerobic metabolism. The basic fact is that estrogen can be a tremendous support for lifelong health, but only if it is safely and efficiently metabolized. Maintaining healthy hormonal balance no matter your age improves how you look and feel. I3C is highly unstable and can transform into many other substances whose actions are undesirable.ĭIM, is the most active dietary indole in cruciferous vegetables, is a healthy stimulus for the beneficial metabolism of estrogen in men and woman. Though still marketed as a dietary supplement, it turns out that I3C (Indole-3-carbinol) is not active in your body until it has converted into DIM. Makes estrogen metabolize down the 2-hydroxy estrone pathway.The ‘good’ estrogen metabolites along with increased free testosterone promoted by DIM increase fat mobilization and a fat-burning metabolism. Free testosterone is testosterone that is more active. DIM produces more ‘good’ estrogen metabolites, which compete with testosterone for protein binding, helping to maintain a slightly higher ‘free’ testosterone level. When Diindolylmethane DIM increases the ‘good’ estrogen metabolites, there is a simultaneous reduction in the levels of undesirable or “bad” estrogen metabolites.ĭiindolylmethane DIM contributes to a better metabolism in the most natural way possible by working with your own hormones and adjusting their action to avoid hormonal imbalance. Cruciferous vegetables include cabbage, broccoli, Brussels sprouts, and cauliflower. DIM and other plant indoles are found in all cruciferous vegetables. Scott Connelly, MD.ĭiindolylmethane, or DIM for short, is a plant indole-a plant compound with health-promoting properties. The majority of this article is information obtained from the book “All About DIM” by Michael A.
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